Thursday, 31 May 2018

Lifestyle Changes and Home Remedies for MS

To help relieve the signs and symptoms of MS, try to:
  • Get plenty of rest.
  • Exercise. If you have mild to moderate MS, regular exercise can help improve your strength, muscle tone, balance and coordination. Swimming or other water exercises are good options if you're bothered by heat. Other types of mild to moderate exercise recommended for people with MS include walking, stretching, low-impact aerobics, stationary bicycling, yoga and tai chi.
  • Cool down. MS symptoms often worsen when your body temperature rises. Avoiding exposure to heat and using devices such as cooling scarves or vests can be helpful.
  • Eat a balanced diet. Results of small studies suggest that a diet low in saturated fat but high in omega-3 fatty acids, such as those found in olive and fish oils, may be beneficial. But further research is needed. Studies also suggest that vitamin D may have potential benefit for people with MS.
  • Relieve stress. Stress may trigger or worsen your signs and symptoms. Yoga, tai chi, massage, meditation or deep breathing may help.

Alternative Medicine for MS

Many people with MS use a variety of alternative or complementary treatments or both to help manage their symptoms, such as fatigue and muscle pain.

Activities such as exercise, meditation, yoga, massage, eating a healthier diet, acupuncture and relaxation techniques may help boost overall mental and physical well-being, but there are few studies to back up their use in managing symptoms of MS.

Join us to know more about treatments of Multiple Sclerosis at the International #Conference on
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Wednesday, 30 May 2018

Treatment for Relapsing-remitting MS

  • Beta interferons. These medications are among the most commonly prescribed medications to treat MS.
  • Ocrelizumab (Ocrevus). This humanized immunoglobulin antibody medication is the only DMT approved by the FDA to treat both the relapse-remitting and primary progressive forms of MS. Clinical trials showed it reduced relapse rate in relapsing disease and slowed worsening of disability in both forms of the disease.
  • Glatiramer acetate (Copaxone). This medication may help block your immune system's attack on myelin and must be injected beneath the skin. Side effects may include skin irritation at the injection site.
  • Dimethyl fumarate (Tecfidera). This twice-daily oral medication can reduce relapses. Side effects may include flushing, diarrhea, nausea and lowered white blood cell count.
  • Fingolimod (Gilenya). This once-daily oral medication reduces relapse rate.
  • Teriflunomide (Aubagio). This once-daily medication can reduce relapse rate. Teriflunomide can cause liver damage, hair loss and other side effects.
  • Natalizumab (Tysabri). This medication is designed to block the movement of potentially damaging immune cells from your bloodstream to your brain and spinal cord.
  • Alemtuzumab (Lemtrada). This drug helps reduce relapses of MS by targeting a protein on the surface of immune cells and depleting white blood cells.
  • Mitoxantrone. This immunosuppressant drug can be harmful to the heart and is associated with development of blood cancers.
#May30th #WorldMSDay International Conference on Alzheimers, Dementia and Related Neurodegenerative Diseases is coming up with a session on Multiple Sclerosis... Submit your abstracts to be a part of the conference and to present your work... Submit via: https://alzheimers-dementia.pulsusconference.com/abstract-submission

Monday, 28 May 2018

Treatments for Multiple Sclerosis attacks

  • Corticosteroids, such as oral prednisone and intravenous methylprednisolone, are prescribed to reduce nerve inflammation. Side effects may include insomnia, increased blood pressure, mood swings and fluid retention.
  • Plasmaexchange (plasmapheresis). The liquid portion of part of your blood (plasma) is removed and separated from your blood cells. The blood cells are then mixed with a protein solution (albumin) and put back into your body. Plasma exchange may be used if your symptoms are new, severe and haven't responded to steroids.

Treatments for MS signs and symptoms

  • Physical Therapy. A physical or occupational therapist can teach you stretching and strengthening exercises and show you how to use devices to make it easier to perform daily tasks. Physical therapy along with the use of a mobility aid when necessary can also help manage leg weakness and other gait problems often associated with MS.
  • Muscle Relaxants. You may experience painful or uncontrollable muscle stiffness or spasms, particularly in your legs. Muscle relaxants such as baclofen (Lioresal) and tizanidine (Zanaflex) may help.
  • Medications to reduce fatigue.
  • Other Medications. Medications also may be prescribed for depression, pain, sexual dysfunction, and bladder or bowel control problems that are associated with MS.
International Conference on Alzheimers, Dementia and Related Neurodegenerative Diseases is coming up with a session on Multiple Sclerosis, submit your abstracts via https://bit.ly/2HlLuhx to be a part of our conference. Register Now!!!

Diagnosis of Multiple Sclerosis

There are no specific tests for MS. Instead, a diagnosis of multiple sclerosis often relies on ruling out other conditions that might produce similar signs and symptoms, known as a differential diagnosis.

Doctor is likely to start with a thorough medical history and examination. These tests may be recommended by doctor:
  • Blood Tests, to help rule out other diseases with symptoms similar to MS. Tests to check for specific bio-markers associated with MS are currently under development and may also aid in diagnosing the disease.
  • Lumbar Puncture (Spinal Tap), in which a small sample of fluid is removed from your spinal canal for laboratory analysis. This sample can show abnormalities in antibodies that are associated with MS. Spinal tap can also help rule out infections and other conditions with symptoms similar to MS.
  • MRI, which can reveal areas of MS (lesions) on your brain and spinal cord. You may receive an intravenous injection of a contrast material to highlight lesions that indicate your disease is in an active phase.
  • Evoked Potential Tests, which record the electrical signals produced by your nervous system in response to stimuli. An evoked potential test may use visual stimuli or electrical stimuli, in which you watch a moving visual pattern, or short electrical impulses are applied to nerves in your legs or arms. Electrodes measure how quickly the information travels down your nerve pathways.
In most people with relapsing-remitting MS, the diagnosis is fairly straightforward and based on a pattern of symptoms consistent with the disease and confirmed by brain imaging scans, such as MRI.

If you have done research on Multiple Sclerosis you can present your research at #Alzheimers 2018 by submitting your work at https://bit.ly/2HlLuhx. To Know more about the diagnosis of Multiple Sclerosis, Join us at the International Conference on #Alzheimers, #Dementia and Related #Neurodegenerative Diseases at Madrid, Spain on 27-28 August, 2018. 

Friday, 25 May 2018

Complications of Multiple Sclerosis

Because the effects of nerve injury are widespread, the many complications can be very severe and affect all parts of the body. Although not all individuals with multiple sclerosis (MS) experience all of the following complications, any of them can negatively affect the individual's quality of life.
  • Fatigue: Fatigue is one of the most common and debilitating MS symptoms and affects at least two thirds of patients with MS. Fatigue causes a general lack of energy that significantly limits daily functioning regardless of any neurologic symptoms or specific muscle weaknesses.
  • Loss of mobility and spasticity: Nearly every individual with MS loses some mobility, which may take the form of impaired motor control, muscle weakness, impaired balance, tremor, and, importantly, spasticity. Spasticity is one of the primary symptoms of MS.
  • Pain: About two-thirds of MS patients experience pain at some point during the course of the disease and 40% are never pain free.
  • Bowel dysfunction: Bowel dysfunction, which can include constipation or faecal incontinence, is a serious problem for many MS patients. Constipation may be caused by the disorder itself or by medications used to treat spasms or other symptoms. Diarrhoea may also occur.
  • Sexual dysfunction: Sexual dysfunction is a common problem in those with MS, occurring in over 70% of patients. Men are likely to have impotence and women have problems with vaginal lubrication, both leading to sexual dysfunction. It appears to be highly associated with urinary dysfunction.
  • Urinary urgency or hesitancy: Individuals with urinary urgency feel the need to urinate frequently and urgently and initiating difficulty in urination respectively.
  • Incontinence: Incontinence is the loss of bladder control. Sometimes MS will disrupt the nerve signals sent to the body parts that control urine movement allowing urine to be expelled involuntarily.
  • Nocturia: Individuals with nocturia must awake frequently during the night to go to the bathroom.
  • Visual problems: Vision problems that can occur with MS include: blurred or dimmed vision; pain with eye movement; blind spots, particularly involving central vision; color blindness; double vision; and nystagmus, or vision that jumps uncontrollably.
  • Difficulty swallowing: One-third to one-half of MS patients experience difficulty in chewing or swallowing, problems that may be caused or made worse by many MS medications.
  • Speech and hearing problems: Problems in speech may occur because of difficulty in controlling the quality of the voice and articulating words.
  • Lung problems: As the muscles that control breathing weaken, the ability to cough is impaired and the individual with MS is at higher risk for pneumonia and other complications in the lungs.
  • Osteoporosis: Osteoporosis, or the loss of bone density, and subsequent fractures are a common problem among individuals with MS.
  • Cognitive problems: Cognitive problems, such as having trouble concentrating and solving problems, affect about half of MS patients.
  • Depression: Between 40-60% of MS patients suffer from depression at some point over the course of the illness, and studies have reported risks for suicide ranging from 3-15%.

Risk Factors of Multiple Sclerosis

These factors may increase your risk of developing multiple sclerosis:
  • Age. Multiple Sclerosis can occur at any age, but most commonly affects people between the ages of 15 and 60.
  • Sex. Women are about twice as likely as men are to develop MS.
  • Family history. If one of your parents or siblings has had MS, you are at higher risk of developing the disease.
  • Certain infections. A variety of viruses have been linked to MS, including Epstein-Barr, the virus that causes infectious mononucleosis.
  • Race. White people, particularly those of Northern European descent, are at highest risk of developing MS. People of Asian, African or Native American descent have the lowest risk.
  • Climate. MS is far more common in countries with temperate climates, including Canada, the northern United States, New Zealand, southeastern Australia and Europe.
  • Certain autoimmune diseases. You have a slightly higher risk of developing MS if you have thyroid disease, type 1 diabetes or inflammatory bowel disease.
  • Smoking. Smokers who experience an initial event of symptoms that may signal MS are more likely than nonsmokers to develop a second event that confirms relapsing-remitting MS.
To be a part of International #Conference on #Alzheimers, #Dementia and Related #Neurodegenerative Diseases... You can submit your abstracts for the talk at https://alzheimers-dementia.pulsusconference.com/abstract-submission ... Visit our page to know more about the conference https://alzheimers-dementia.pulsusconference.com/

Wednesday, 23 May 2018

Causes of Multiple Sclerosis

The cause of multiple sclerosis is unknown. It's considered an autoimmune disease in which the body's immune system attacks its own tissues. In the case of MS, this immune system malfunction destroys myelin (the fatty substance that coats and protects nerve fibers in the brain and spinalcord).

Myelin can be compared to the insulation coating on electrical wires. When the protective myelin is damaged and nerve fiber is exposed, the messages that travel along that nerve may be slowed or blocked. The nerve may also become damaged itself.

It isn't clear why MS develops in some people and not others. A combination of genetics and environmental factors appears to be responsible.

To know more about Multiple Sclerosis Join us at the International Conference on #Alzheimers, #Dementia and Related #Neurodegenerative Diseases at https://bit.ly/2HlLuhx

Tuesday, 22 May 2018

Course of Multiple Sclerosis

Most people with Multiple Sclerosis have a relapsing-remitting disease course. They experience periods of new symptoms or relapses that develop over days or weeks and usually improve partially or completely. These relapses are followed by quiet periods of disease remission that can last months or even years.

Small increases in body temperature can temporarily worsen signs and symptoms of MS, but these aren't considered disease relapses.

About 60 to 70 percent of people with relapsing-remitting MS eventually develop a steady progression of symptoms, with or without periods of remission, known as secondary-progressive MS.

The worsening of symptoms usually includes problems with mobility and gait. The rate of disease progression varies greatly among people with secondary-progressive MS.

Some people with MS experience a gradual onset and steady progression of signs and symptoms without any relapses. This is known as primary-progressive MS.

Multiple Sclerosis is a disease in which the immune system eats away at the protective covering of nerves. To know more about the disease you can join us at the International Conference on #Alzheimers, #Dementia and Related #Neurodegenerative Diseases on 27-28 August, 2018 at Madrid, Spain.. To know more visit: https://alzheimers-dementia.pulsusconference.com/ or drop us a mail at alzheimers@pulsusmeet.com

Symptoms of Multiple Sclerosis

Multiple sclerosis signs and symptoms may differ greatly from person to person and over the course of the disease depending on the location of affected nerve fibers. They may include:
  • Numbness or weakness in one or more limbs that typically occurs on one side of your body at a time, or the legs and trunk
  • Partial or complete loss of vision, usually in one eye at a time, often with pain during eye movement
  • Prolonged double vision
  • Tingling or pain in parts of your body
  • Electric-shock sensations that occur with certain neck movements, especially bending the neck forward (Lhermitte sign)
  • Tremor, lack of coordination or unsteady gait
  • Slurred speech
  • Fatigue
  • Dizziness
  • Problems with bowel and bladder function
To know more about the recent research going on in the field of Multiple Sclerosis, join us at the International Conference on #Alzheimers, #Dementia and Related #Neurodegenerative Diseases https://bit.ly/2HlLuhx

Monday, 21 May 2018

Multiple Sclerosis

Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system).

In MS, the immune system attacks the protective sheath (myelin) that covers nerve fibers and causes communication problems between your brain and the rest of your body. Eventually, the disease can cause the nerves themselves to deteriorate or become permanently damaged.

Signs and symptoms of MS vary widely and depend on the amount of nerve damage and which nerves are affected. Some people with severe MS may lose the ability to walk independently or at all, while others may experience long periods of remission without any new symptoms.

There's no cure for multiple sclerosis. However, treatments can help speed recovery from attacks, modify the course of the disease and manage symptoms.

International Conference on #Alzheimers, #Dementia and Related #Neurodegenerative Diseases which is scheduled on 27-28 August, 2018 at Madrid, Spain is coming up with a session on Multiple Sclerosis... Submit your abstracts to be a part of the largest gathering of Neurology Experts from all over the world... You can submit your abstracts at https://bit.ly/2HlLuhx

Thursday, 17 May 2018

Prevention of Epilepsy

If the seizures are related to another medical condition, identification and treatment of that medical condition is the key to prevention. If anticonvulsant medication is prescribed, taking the medication on the recommended schedule and not missing medication is important.
  • Some people with epilepsy are quite sensitive to alcohol. If this pattern develops, avoid alcohol. Others may have seizures only after ceasing heavy alcohol intake. The key to prevention is avoidance of alcohol.
  • Sleep deprivation and stress certainly may increase the frequency of seizures in some people with epilepsy.

Epilepsy Outlook

Epilepsy simply describes the condition of recurrent seizures. The outcome of the seizure disorder is strongly related to the cause of the seizures, if a cause is discovered.

For people with symptomatic epilepsy-that is, seizures that occur because other medical conditions exist -prognosis will depend on the other medical condition.
  • Seizures resulting from low blood sugars, for example, could be prevented by careful management and avoidance of hypoglycemia (low blood sugar).
  • Seizures related to progressive medical conditions such as some brain tumors or metabolic conditions may be difficult to control and may have a poor outcome.
Be a part of the International Conference on #Alzheimers, #Dementia and Related #Neurodegenerative Diseases by submitting your abstract of the talk at https://bit.ly/2HlLuhx

Wednesday, 16 May 2018

Self-Care at Home for Epilepsy

Home care with epilepsy varies with the frequency and type of seizures. It is important to take anticonvulsant medication regularly to prevent seizures.

When a seizure occurs, an observer can use common sense to prevent injuries.
  • Cushion the person's head.
  • Loosen any tight neckwear.
  • Turn the person on his or her side.
  • Do not hold the person down or restrain the person.
  • Do not place anything in the mouth or try to pry the teeth apart. The person is not in danger of swallowing his or her tongue.
  • Observe seizure characteristics-length, type of movements, direction of head or eye turning. These characteristics may help the doctor diagnose the type of seizure.
To know more about how to deal with Epilepsy... Join us at Madrid, Spain on 27-28 August, 2018 by participating at the International Conference on #Alzheimers, #Dementia and Related #Neurodegenerative Diseases... Book your slots at https://bit.ly/2HlLuhx



Tuesday, 15 May 2018

Life Expectancy of People with Epilepsy

Epilepsy carries a risk of premature mortality, but little is known about life expectancy in people with the condition. 

In 2013, researchers from the University of Oxford and University College London in the U.K. reported that people with epilepsy are 11 times more likely to experience premature death, compared with the rest of the population.

The risk appears to be greater if the person also has a mental illness. Suicides, accidents, and assaults accounted for 15.8 percent of early deaths. Most people affected by these had also been diagnosed with a mental disorder.

Head researcher, Seena Fazel said:

"Our results have significant public health implications, as around 70 million people worldwide have epilepsy, and they emphasize that carefully assessing and treating psychiatric disorders as part of standard checks in persons with epilepsy could help reduce the risk of premature death in these patients. Our study also highlights the importance of suicide and non-vehicle accidents as major preventable causes of death in people with epilepsy."

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Can epilepsy lead to brain damage?

A study published in 2005 suggested that people with severe epilepsy who continue to experience seizures were more likely to have difficulties with cognitive ability and brain function. Longer periods of remission were linked with fewer cognitive problems.

A review published in 2006 concluded that there may be a "mild but measurable" decline in some people in intellectual performance" of adults and children.

However, the researchers point out that there is little reliable research in this area, and that "Due to many confounding variables, the effect of seizures per se is difficult to estimate, but appears limited."

Recent studies have looked at cognitive changes in children as they age, either with or without epilepsy. Results suggest that epilepsy is associated with worse cognitive outcomes.

However, it is unclear whether:
  • epilepsy causes the impairment
  • a similar structural change causes both the epilepsy and the impairment
  • anti-epileptic drugs have an effect
This is an area that needs further research

Other effects

Epilepsy can affect various aspects of a person's life, including:
  • emotions and behavior
  • social development and interaction
  • ability to study and work
  • The impact on these areas of life will depend largely on the frequency and severity of seizures.
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Monday, 14 May 2018

Epilepsy vs. Seizures

Seizures are the only symptom of epilepsy. Epilepsy is defined as having "two or more unprovoked seizures," according to Johns Hopkins Medicine.

Some people have a single seizure, or seizures that are not linked to epilepsy. According to the United Kingdom's Epilepsy Society, non-epileptic seizures are not due to electrical activity in the brain. The causes can be physical, emotional, or psychological.

There are also different types of seizure. Seizures may vary between people with epilepsy, so in two individuals, the condition may look different. For this reason, it can be called a spectrum disorder.

Outlook

Epilepsy can affect a person's life in multiple ways, and the outlook will depend on various factors.

Will seizures continue?

If the cause is clearly identifiable, seizures are more likely to continue.

Other factors affecting the chances of remission include:
  • access to treatment
  • response to treatment
  • age when symptoms started
  • other neurological condition the person may have
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Thursday, 10 May 2018

Treatment of Epilepsy

There is currently no cure for most types of epilepsy. However, surgery can stop some kinds of seizure from occurring, and in many cases, the condition can be managed.

If an underlying correctable brain condition is causing the seizures, sometimes surgery can stop them. If epilepsy is diagnosed, the doctor will prescribe seizure-preventing drugs or anti-epileptic drugs.

If drugs do not work, the next option could be surgery, a special diet or VNS (vagus nerve stimulation).

The doctor's aim is to prevent further seizures from occurring, while at the same time avoiding side effects so that the patient can lead a normal, active, and productive life. 

Anti-epileptic drugs (AEDs)

The majority of AEDs are taken orally. The type of seizure the patient is having will decide which drug the doctor may prescribe. Patients do not all react in the same way to drugs, but AEDs appear to help control seizures in 70 percent of cases.

Drugs commonly used to treat epilepsy include:

  • sodium valproate
  • carbamazepine
  • lamotrigine
  • levetiracetam
Some drugs may stop seizures in one patient, but not in another. Even when the right drug is found, it can take some time to find the ideal dose.

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Epileptic Seizures

There are three descriptions of seizures, depending on where in the brain the activity started.

Partial Seizure
A partial seizure means the epileptic activity took place in just part of the patient's brain. There are two types of partial seizure:

Simple partial seizure - the patient is conscious during the seizure. In most cases, the patient is also aware of their surroundings, even though the seizure is in progress.

Complex partial seizure - the patient's consciousness is impaired. The patient will generally not remember the seizure, and if they do, their memory will be vague.

Generalized Seizure
A generalized seizure occurs when both halves of the brain have epileptic activity. The patient's consciousness is lost while the seizure is in progress.

Tonic-clonic seizures (previously known as grand mal seizures): Perhaps the best known type of generalized seizure. They cause a loss of consciousness, body stiffness, and shaking.

Absence seizures: Previously called petit mal seizures, these involve short lapses in consciousness where the individual appears to be staring off into space. Absence seizures often respond well to treatment.

Tonic seizures: Muscles become stiff, and the person may fall.

Atonic seizures: A loss of muscle control causes the individual to drop suddenly.

Clonic seizures: This is associated with rhythmic, jerking movements.

Secondary Generalized Seizure

A secondary generalized seizure occurs when the epileptic activity starts as a partial seizure, but then spreads to both halves of the brain. As this development happens, the patient loses consciousness.

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Wednesday, 9 May 2018

Causes: How does a person get epilepsy?

A person with epilepsy will have recurrent seizures.
Every function in the human body is triggered by messaging systems in our brain. Epilepsy results when this system is disrupted due to faulty electrical activity.

In many cases, the exact cause is not known. Some people have inherited genetic factors that make epilepsy more likely to occur.

Other factors that may increase the risk include:
  • head trauma, for instance, during a car crash
  • brain conditions, including stroke or tumors
  • infectious diseases, for instance, AIDS and viral encephalitis
  • prenatal injury, or brain damage that occurs before birth
  • developmental disorders, for instance, autism or neurofibromatosis
It is most likely to appear in children under 2 years of age, and adults over 65 years.

What a patient with epilepsy experiences during a seizure will depend on which part of the brain is affected, and how widely and quickly it spreads from that area.

Join us at the International Conference on Alzheimers, Dementia and Related Neurodegenerative Diseases to know more about Epilepsy and many other Diseases. https://bit.ly/2p9olWH

Tuesday, 8 May 2018

Epilepsy symptoms

Epilepsy is a neurological condition.
The main symptom of epilepsy is repeated seizures. If one or more of the following symptoms are present, the individual should see a doctor, especially if they recur:
  • a convulsion with no temperature (no fever)
  • short spells of blackout, or confused memory
  • intermittent fainting spells, during which bowel or bladder control is lost, which is frequently followed by extreme tiredness
  • for a short period, the person is unresponsive to instructions or questions and becomes stiff
  • the person suddenly falls for no clear reason
  • sudden bouts of blinking and chewing without apparent stimuli and apparent reason
  • for a short time the person seems dazed and unable to communicate
  • the person becomes fearful for no apparent reason; they may even panic or become angry
  • peculiar changes in senses, such as smell, touch, and sound
  • the arms, legs, or body jerk, in babies these will appear as a cluster of rapid jerking movements

The following conditions need to be eliminated. They may present similar symptoms and are sometimes misdiagnosed as epilepsy:
  • high fever with epilepsy-like symptoms
  • fainting
  • narcolepsy, or recurring episodes of sleep during the day
  • cataplexy, or periods of extreme muscle weakness
  • sleep disorders
  • nightmares
  • panic attacks
  • fugue states, a rare psychiatric disorder
  • psychogenic seizures
To know more about Epilepsy and other Neurodegenerative Diseases, Join us at the International Conference on Alzheimers, Dementia and Related Neurodegenerative Diseases https://bit.ly/2p9olWH

Monday, 7 May 2018

Epilepsy

People with epilepsy experience recurrent seizures, because a sudden surge of electrical activity in the brain causes a temporary disturbance in the messaging systems between brain cells.

The Centers for Disease Control and Prevention (CDC) describe epilepsy as "a common neurological condition characterized by recurrent seizures."

Here are some key points about epilepsy

Epilepsy is a neurological disorder.
Primary symptoms commonly include seizures.
Seizures have a range of severity depending on the individual.
Treatments include anti-seizure medications.

To know more about #Epilepsy and other Neurodegenerative Diseases, Join us at the International Conference on #Alzheimers, #Dementia and Related #Neurodegenerative #Diseases https://bit.ly/2p9olWH 

Friday, 4 May 2018

Alzheimer's Disease Fact Sheet

Alzheimer's disease is currently ranked as the sixth leading cause of death in the United States, but recent estimates indicate that the disorder may rank third, just behind heart disease and cancer, as a cause of death for older people.

Alzheimer’s is the most common cause of dementia among older adults. Dementia is the loss of cognitive functioning—thinking, remembering, and reasoning—and behavioral abilities to such an extent that it interferes with a person’s daily life and activities. Dementia ranges in severity from the mildest stage, when it is just beginning to affect a person’s functioning, to the most severe stage, when the person must depend completely on others for basic activities of daily living.

The causes of dementia can vary, depending on the types of brain changes that may be taking place. Other dementias include Lewy body dementia, frontotemporal disorders, and vascular dementia. It is common for people to have mixed dementia—a combination of two or more disorders, at least one of which is dementia. For example, some people have both Alzheimer's disease and vascular dementia.

Alzheimer’s disease is named after Dr. Alois Alzheimer. In 1906, Dr. Alzheimer noticed changes in the brain tissue of a woman who had died of an unusual mental illness. Her symptoms included memory loss, language problems, and unpredictable behavior. After she died, he examined her brain and found many abnormal clumps (now called amyloid plaques) and tangled bundles of fibers (now called neurofibrillary, or tau, tangles).

These plaques and tangles in the brain are still considered some of the main features of Alzheimer’s disease. Another feature is the loss of connections between nerve cells (neurons) in the brain. Neurons transmit messages between different parts of the brain, and from the brain to muscles and organs in the body.

To know more about Alzheimer's Disease.... Join us at the International Conference on #Alzheimers, #Dementia and Related #Neurodegenerative #Diseases https://bit.ly/2p9olWH


Thursday, 3 May 2018

Health, Environmental, and Lifestyle Factors for Alzheimer's Disease

Research suggests that a host of factors beyond genetics may play a role in the development and course of Alzheimer’s disease. There is a great deal of interest, for example, in the relationship between cognitive decline and vascular conditions such as heart disease, stroke, and high blood pressure, as well as metabolic conditions such as diabetes and obesity. Ongoing research will help us understand whether and how reducing risk factors for these conditions may also reduce the risk of Alzheimer’s.

A nutritious diet, physical activity, social engagement, and mentally stimulating pursuits have all been associated with helping people stay healthy as they age. These factors might also help reduce the risk of cognitive decline and Alzheimer’s disease. Clinical trials are testing some of these possibilities.

To know more about Alzheimer's Disease and other related Neurodegenerative Diseases, Join us at the International Conference on #Alzheimers, #Dementia and Related #Neurodegenerative #Diseases.... Submit your Abstracts and Register now to avail Early Bird Discounts... https://bit.ly/2p9olWH... For more information drop us a mail at alzheimers@neurologistssociety.com  

Wednesday, 2 May 2018

Genetics and Alzheimer's Disease

Most people with Alzheimer’s have the late-onset form of the disease, in which symptoms become apparent in their mid-60s. The apolipoprotein E (APOE) gene is involved in late-onset Alzheimer’s. This gene has several forms. One of them, APOE ε4, increases a person’s risk of developing the disease and is also associated with an earlier age of disease onset. However, carrying the APOE ε4 form of the gene does not mean that a person will definitely develop Alzheimer’s disease, and some people with no APOE ε4 may also develop the disease.

Also, scientists have identified a number of regions of interest in the genome (an organism's complete set of DNA) that may increase a person's risk for late-onset Alzheimer's to varying degrees.

Early-onset Alzheimer’s disease occurs between a person’s 30s to mid-60s and represents less than 10 percent of all people with Alzheimer’s. Some cases are caused by an inherited change in one of three genes, resulting in a type known as early-onset familial Alzheimer’s disease, or FAD. For other cases of early-onset Alzheimer’s, research suggests there may be a genetic component related to factors other than these three genes.

Most people with Down syndrome develop Alzheimer's. This may be because people with Down syndrome have an extra copy of chromosome 21, which contains the gene that generates harmful amyloid.

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Tuesday, 1 May 2018

The role of plaques and tangles in Alzheimer's Disease

Two abnormal structures called plaques and tangles are prime suspects in damaging and killing nerve cells.

Plaques are deposits of a protein fragment called beta-amyloid that build up in the spaces between nerve cells.

Tangles are twisted fibers of another protein called tau that build up inside cells.

Though autopsy studies show that most people develop some plaques and tangles as they age, those with Alzheimer’s tend to develop far more and in a predictable pattern, beginning in the areas important for memory before spreading to other regions.

Scientists do not know exactly what role plaques and tangles play in Alzheimer's disease. Most experts believe they somehow play a critical role in blocking communication among nerve cells and disrupting processes that cells need to survive.

It's the destruction and death of nerve cells that causes memory failure, personality changes, problems carrying out daily activities and other symptoms of Alzheimer's disease.

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7 Possible Reasons You’re Having Those Weird Memory Lapses

You’re in the middle of telling a story about your friend’s dog when a memory lapse strikes and—poof! —the name of the pup disappears from...