Wednesday, 18 July 2018

‘Nano scope’ zooms in to see Alzheimer’s plaques

A major problem with understanding Alzheimer’s is not being able to clearly see why the disease starts. Now, a super-resolution “nanoscope” offers a 3D view of brain molecules with 10 times greater detail than ever before.

Recent studies show that 40 percent of Americans over the age of 85 have Alzheimer’s disease. Further, the disease begins 10 to 20 years before people ever show up at the doctor’s office with memory problems.

The instrument helped researchers better understand the structure of plaques that form in the brain of Alzheimer’s patients, pinpointing characteristics that are possibly responsible for damage.

“It gives insight into the biological causes of the disease, so that we can see if we can stop the formation of these damaging structures in the brain.”

To know more about the current research on #Alzheimer's Disease, join us at the International #Conference on #Alzheimers, Dementia and Related #Neurodegenerative Diseases which is scheduled on #December 03-04, 2018 at #Madrid, Spain.

Tuesday, 17 July 2018

What is the difference between Dementia and Alzheimer’s disease?

The two terms are often mixed up or used interchangeably, which can be confusing.

To put it simply, dementia is not a disease in its own right. Dementia is the name for a group of symptoms that commonly include problems with memory, thinking, problem solving, language and perception.

Dementia is caused by different diseases that affect the brain. Alzheimer’s disease is the most common. Some other common types of dementia include vascular dementia and dementia with Lewy bodies.

While dementia and Alzheimer’s disease are related, there are key differences between the two.

What is dementia?
When a person receives a dementia diagnosis they should also learn what type of dementia they have. This is not always the case, and sometimes the term ‘dementia’ is used to describe the symptoms they may be experiencing. These symptoms might include memory loss or difficulties with language or concentration.

Dementia is caused by diseases which damage the brain by causing a loss of nerve cells. Alzheimer’s disease is one specific cause of dementia (and the most common). Some other causes of dementia include:
  • Vascular dementia, where a lack of oxygen to the brain causes nerve cells to die. This can be caused by a stroke, a series of mini strokes or a disease of the small blood vessels in the brain
  • Mixed dementia, where someone has more than one type of dementia and a mix of symptoms
  • Dementia with Lewy bodies, where abnormal structures – Lewy bodies – form in the brain and cause the death of nerve cells
  • Frontotemporal dementia, where clumps of abnormal protein form in front and side parts of the brain and cause the death of nerve cells.
What is Alzheimer’s disease?
Alzheimer’s disease is a physical disease that affects the brain. Abnormal structures called ‘plaques’ and ‘tangles’ build up inside the brain. These disrupt how nerve cells work and communicate with each other, and eventually cause them to die. There is also a shortage of some important chemicals in the brain of someone with Alzheimer’s disease. Reduced levels of these chemicals mean that messages don’t travel around as well as they should.

Alzheimer’s disease usually begins gradually with mild memory loss, such as difficulty recalling recent events or learning new information. Other symptoms may include difficulties finding the right words, solving problems, making decisions, or perceiving things in three dimensions.

As Alzheimer’s progresses, problems with memory loss, communication, reasoning and orientation become more severe. The person will need more day-to-day support from those who care for them.
There is currently no cure for Alzheimer’s disease. However, treatments may temporarily ease some symptoms or slow down their progression in some people.

Source: Alzheimer's Society

Monday, 16 July 2018

How to Talk to a Loved One About Signs of Alzheimer’s Disease

Every year, Alzheimer’s disease affects a growing number of people. Currently, about 5.7 million Americans are living with the condition, according to the Alzheimer’s Association. By 2020, nearly 14 million are expected to have this progressive brain disorder, which destroys memory, thinking skills, and often the ability to carry out simple tasks.

7 Tips for Talking About Alzheimer’s

Drew stresses that although Alzheimer’s and Brain Awareness Month has just ended this June, we need to keep the conversation about Alzheimer’s going all year long and learn how to talk about the disease with family and friends.

Here are a few tips that can help people broach the subject of dementia with someone who may be developing the condition.
  • Recognize the Signs and Symptoms
  • Don’t Put Off the Conversation
  • Pick a Comfortable Time and Setting
  • Keep Trying No Matter How Much Push-back You Get
  • Get Family and Healthcare Providers Involved
  • Create a Concrete Plan
  • Reach Out for Professional Help
#Alzheimers2018 is scheduled on 03-04 December, 2018 at Madrid, Spain with the theme of Leading #Advancements and #Remedies in the #Neurodegenerative Disorders

Thursday, 12 July 2018

‘Skinny fat’ body type could be predictor of Alzheimer’s risk

If you’re considered sarcopenic obese, or “skinny fat,” beware. Your body type could be linked to dementia, according to a new report. 

Researchers from Florida Atlantic University’s Comprehensive Centre for Brain Health recently conducted a study to determine the link between obesity, low muscle tissue and dementia, which is an early sign of Alzheimer’s disease. 

To do so, they used data from a series of aging and memory studies that examined 353 people with an average of 69. The researchers evaluated the individuals who were “skinny fat,” the combination of low muscle mass and strength in the context of high fat mass, and their performances on various cognition tests

After analysing the results, they found that the “skinny fat” subjects had the lowest performance on global cognition, followed by those with just sarcopenia alone and then those who were only obese.

Join us at the Leading Pharma Event #Alzheimers2018 at Madrid, Spain on December 03-04, 2018.

New Tool for Studying Alzheimer’s Disease

Scientists in Dresden, Germany, have been successful in mimicking mechanisms of Alzheimer's disease in a novel, stem cell-based model system that reproduces features of human brain tissue. This experimental tool can be used to study mechanisms of pathology and help to find new therapeutic approaches, the researchers say. Their results, published in DevelopmentalCell, indicate that modulating the immune system can trigger neuronal repair processes and thus possibly help the brain to better cope with Alzheimer's.

The study involved the German Centre for Neurodegenerative Diseases (DZNE), the Leibniz Institute of Polymer Research Dresden (IPF), the Centre for Regenerative Therapies Dresden at the TU Dresden (CRTD) and further institutions from Germany and abroad.

By using the new disease model, the researchers discovered an approach to instruct stem cells to produce neurons and kick-start repair processes, i.e. 'neuronal regeneration'.

"Neural stem cells are the progenitors of neurons. They occur naturally in the brain and as such they constitute a reservoir for new neurons. However, in Alzheimer's neural stem cells lose this ability and therefore cannot replace neurons lost due to the disease," explains Dr. Caghan Kizil, head of the current study and research group leader at the DZNE and the CRTD.

"Our results suggest that modulating the immune system can unlock the potential of neural stem cells to build new neurons. These new cells foster regeneration and could possibly help the brain to better cope with the disease. This points to a potential approach to therapy, which we intend to further explore. If it will work out in humans, we cannot say at this stage. At present, this is still fundamental research."

Wednesday, 11 July 2018

Scientists Looking at Brain Stimulation as a Possible Treatment for Alzheimer’s

Sending electronic pulses through a brain that is being damaged by Alzheimer’s disease might become a new method of early treatment.

A study headed by Dr. Andres Lozano at Toronto Western Hospital’s Krembil Neuroscience Centre in Canada, has concluded that patients over the age of 65 with mild Alzheimer’s disease can benefit from deep brainstimulation.

Deep brain stimulation is nothing new but using it as a more targeted therapy could yield dividends.

“Deep brain stimulation (DBS) implants have been used for over 30 years, mostly to treat the tremors of Parkinson’s disease patients,” Dr. Doug Scharre, director of the Division of Cognitive Neurology at The Ohio State University Wexner Medical Centre, told Healthline.

Scharre notes that while DBS treatment is approved by the Food and Drug Administration (FDA) for Parkinson’s disease, it’s still an experimental therapy when it comes to Alzheimer’s.

To know more about the current research on #Alzheimer's Disease, join us at the International #Conference on #Alzheimers, Dementia and Related #Neurodegenerative Diseases which is scheduled on #December 03-04, 2018 at #Madrid, Spain

Tuesday, 10 July 2018

Finding a New Path with Dementia

Dementia is an umbrella term for a range of neurological disorders, with symptoms such as a loss of memory skills and thinking abilities and changes in behavior that interfere with a person’s everyday functioning. There are many different types of dementia, including Alzheimer’s disease, vascular dementia and Lewy-body dementia. Hearing the word dementia likely conjures up images of people in the final stages, as sufferers curled up on a bed, unable to speak or to recognize loved ones. There is no cure yet, although research continues. Nearly 6 million Americans live with dementia, and diagnoses are expected to spike as the population ages.

But as the first wave of baby boomers begins to be affected by dementia, perceptions of the disease are gradually beginning to change. Some with early symptoms are speaking out, hoping to counter dementia’s stigma and to pursue a higher quality of life as they confront the disease. Advocates are pushing for more life-enhancing kinds of care, such as tools and resources for people recently diagnosed to help make the best of their remaining strengths.

It doesn’t mean that living with dementia can suddenly become easier, or that there’s a simple fix to the challenges a diagnosis presents. But the goal is to flip the script and stop defining people with dementia only as sufferers who are dying from it. “This concept is just taking off,” says Katie Maslow, a visiting scholar at the Gerontological Society of America and an expert in improving dementia care and supporting caregivers. “It’s so different from where we’ve been. We’re talking about living well with dementia, as opposed to focusing only on all the bad things that are about to happen.”

‘Nano scope’ zooms in to see Alzheimer’s plaques

A major problem with understanding Alzheimer’s is not being able to clearly see why the disease starts. Now, a super-resolution “nanoscope...