The role of plaques and tangles in Alzheimer's Disease

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Two abnormal structures called plaques and tangles are prime suspects in damaging and killing nerve cells.

Plaques are deposits of a protein fragment called beta-amyloid that build up in the spaces between nerve cells.

Tangles are twisted fibers of another protein called tau that build up inside cells.

Though autopsy studies show that most people develop some plaques and tangles as they age, those with Alzheimer’s tend to develop far more and in a predictable pattern, beginning in the areas important for memory before spreading to other regions.

Scientists do not know exactly what role plaques and tangles play in Alzheimer's disease. Most experts believe they somehow play a critical role in blocking communication among nerve cells and disrupting processes that cells need to survive.

It's the destruction and death of nerve cells that causes memory failure, personality changes, problems carrying out daily activities and other symptoms of Alzheimer's disease.

To know more join us at the International Conference on #Alzheimers, #Dementia and Related #Neurodegenerative #Diseases https://bit.ly/2p9olWH

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