Parkinson’s Disease Gene Therapy Clinical Trial Launched in UK

By -
A gene therapy for Parkinson’s disease developed by Swiss biotech Axovant has been used on the first patient in a Phase I/II trial at University College London.

Parkinson’s disease is a neurodegenerative disease, caused by a lack of the neurochemical dopamine in regions of the brain handling motor functions causing debilitating symptoms such as rigidity and tremors.

Gene therapy has the potential to deliver therapeutics to specific areas of the brain, which would cause fewer side effects, such as hallucinations and compulsive behavior, than current treatments.
Axovant’s gene therapy is designed to make the affected neurons produce dopamine by delivering the genetic instructions for making dopamine. The treatment is surgically injected into specific regions of the brain, and theoretically lasts for years after surgery.


The first part of the trial will test the safety of different doses of the therapy. The second part will test its therapeutic effect on motor symptoms of the patients compared with a sham operation. Preliminary results are expected in 2019.

“While we do not yet know if it is effective, it is hoped this therapy will provide patient benefit for many, many years following a single treatment,” stated Thomas Foltynie, the trial’s lead clinician at UCL.

The gene therapy was originally developed by Oxford Biomedica, and licensed to Axovant earlier this year. Notably, like all treatments for Parkinson’s disease at present, it intends to alleviate the symptoms of the disease, but does not stop the disease progression.

University College London is also working with Scottish biotech Synpromics to develop a gene therapy for young-onset Parkinson’s disease. In the US, Voyager Therapeutics is also carrying out a Phase I trial of a gene therapy that makes oral treatments for Parkinson’s disease more efficient.

One hope for slowing the progression of Parkinson’s disease is in Phase I/II. The US company, Sangamo Therapeutics, is testing a gene therapy designed to combat neurodegeneration by making brain cells express chemicals that protect neurons from damage.

Originally published in Labiotech.

Comments

  1. Dr Ogudugu Solution Temple16 November 2018 at 09:13

    GREETINGS everyone out there.. my name is (Robert Lora) I am from CANADA i will never forget the help Dr Ogudugu render to me in my marital life. I have been married for 8 years now and my husband and i love each other very dearly. After 6 years of our marriage my husband suddenly change he was having an affair with a lady outside our marriage, my husband just came home one day he pick up his things and left me and the kids to his mistress outside at this time i was confuse not knowing what to do again because i have lost my husband and my marriage too. i was searching for help in the internet, i saw many people sharing testimony on how Dr Ogudugu help them out with their marital problems so i contacted the email of Dr Ogudugu i told him my problem and i was told to be calm that i have come to the right place were i can get back my husband within the next 48hours, to my greatest surprise my husband came to my office begging me on his knees that i should find a place in my heart to forgive him, that he will never cheat on me again, i quickly ask him up that i have forgiven him. Friends your case is not too hard why don't you give Dr Ogudugu a chance, because i know they will help you to fix your relationship with your Ex Partner. Dr Ogudugu his the best spell caster around to solve any problem for you.
    {1} HIV/AIDS
    {2CANCER
    {3}HERPES
    {4}DIABETES
    (5}HERPERTITIS B

    Email: GREATOGUDUGU@GMAIL.COM
    Call/WhatsApp:+27663492930

    ReplyDelete
  2. Sherman Cowley9 March 2019 at 03:35

    I can see that you are an expert at your field! I am launching a website soon, and your information will be very useful for me.. Thanks for all your help and wishing you all the success in your business. clinical trial drugs

    ReplyDelete

Post a Comment

Popular posts from this blog

There is mounting evidence that herpes leads to Alzheimers Disease

By -
Image
More than 30 million people worldwide suffer from Alzheimer’s disease – the most common form of dementia. Unfortunately, there is no cure, only drugs to ease the symptoms. However, my own research suggests a way to treat the disease. I have found the strongest evidence yet that the herpes virus is a cause of Alzheimer’s, suggesting that effective and safe antiviral drugs might be able to treat the disease. We might even be able to vaccinate our children against it. The virus implicated in Alzheimer’s disease , herpes simplex virus type 1 (HSV1), is better known for causing cold sores. It infects most people in infancy and then remains dormant in the peripheral nervous system (the part of the nervous system that isn’t the brain and the spinal cord). Occasionally, if a person is stressed, the virus becomes activated and, in some people, it causes cold sores. The virus can become active in the brain, perhaps repeatedly, and this probably causes cumulative damage. The likel
Read more

Alzheimers 2018

By -
Image
International #Conference on #Alzheimers, #Dementia and Related #Neurodegenerative Diseases is just 24 days away.. #Pulsus Group invites researchers from different fields of #Neurology to present their work at the event. The #conference will mainly focus on the following #topics: Track 1. Dementia Track 2. Alzheimer and Parkinson Track 3. Epilepsy Track 4. Multiple Sclerosis Track 5. Migraine Track 6. Prion Disease Track 7. Motor Neurone Diseases Track 8. Huntingtons Disease Track 9. Spinocerebellar Ataxia Track 10. Spinal Muscular Atrophy Track 11. Demyelinating Diseases Track 12. Cerebral Palsy Track 13. Cognitive Impairment Track 14. Stroke Track 15. Convulsion Track 16. Neurodegeneration Track 17. Neurorehabilitation Track 18. Neurology Track 19. Neuropathy Track 20. Headache Track 21. Neurologist Know more at:  https://alzheimers-dementia.pulsusconference.com/
Read more

15 Things That Slow Down Alzheimer’s Disease

By -
Image
# Alzheimer’s Disease is a progressive disease that destroys memory and other important mental functions. # Brain cell connections and the cells themselves degenerate and die, eventually destroying memory and other important # mental functions. Memory loss and confusion are the main symptoms. No cure exists, but #medication and management strategies may temporarily improve symptoms. Although there’s no # cure , there are things you can do to help prevent, delay, or slow down Alzheimer’s disease and # dementia . Exercising regularly Getting a good night’s sleep Being MIND-ful about your diet Stress management Socializing Learning new things Lowering high blood pressure and cholesterol Losing weight Brushing and flossing Playing brain games Taking nutritional supplements Protecting your noggin Keeping your gut microbiome healthy Taking medications All of the above Know more at: https://alzheimers-dementia.pulsusconferenc
Read more