How liver health impacts the risk of Alzheimer's?
In a recent research done in University of Pennsylvania in Philadelphia, it was observed that Alzheimer's disease risk is associated
with reduced levels of plasmalogens, a type of phospholipid produced in the
liver. They play key roles in maintaining the health of brain cells.
From the liver, plasmalogens are carried to the brain and
other organs through the blood. Levels of these phospholipids can be measured
through specialized tests that have been devised by Dr. Kling in collaboration
with colleagues from the Alzheimer's Disease Metabolomics Consortium at Duke
University in Durham, NC.
The researchers identified three indices — assessing the
ratios of different plasmalogens to each other, the ratios of plasmalogens to
other lipids, and a combination of these measurements that allow them to determine the amount of
plasmalogen as it relates to cognitive functioning.
Specifically, they were interested in confirming whether
decreased plasmalogen levels were linked with an increased risk of developing
various degrees of cognitive impairment, including: Alzheimer's disease, mildcognitive impairment (MCI), or significant memory concerns (SMC).
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