Administered early, an already approved drug may help stop Alzheimer’s progression
The Alzheimer's disease research community is in a great
deal of flux at the moment. After a series of high-profile clinical trial
failures, rages over whether the current causal hypothesis for the disease is
correct. A new study has revealed novel insights into the early stages of the
disease's development and suggests treatment may only be effective if delivered
before a person becomes symptomatic.
For several decades the generally agreed hypothesis
regarding the main symptomatic cause behind the degenerative effects of
Alzheimer's disease was that the build-up of plaques, composed of a protein
called beta-amyloid, resulted in the systematic destruction of neurons.
But the
big problem that has arisen is that almost all efforts to target this amyloid
build up, in one way or another, have failed. An astounding 99.6 percent of clinical
trials into drugs to help beat Alzheimer's have failed.
Attempting to better explain why amyloid-targeting drugs are
failing in trials, some scientists are beginning to suggest the disease in the
subjects in these trials may have progressed too far to respond effectively.
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