UW Study: Hormone Replacement Therapy Doesn't Increase Risk of Alzheimer's Disease

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There’s some reassuring news for healthy women taking hormone replacement therapy who are concerned about Alzheimer’s disease: University of Wisconsin-Madison research shows no increased risk for the most common type of dementia. But it also didn’t find any benefits to the brain.

Prior to a 2003 landmark study, scientists believed estrogen therapy was protective for the brain and heart. But the Women’s Health Initiative Memory Study (WHIMS) showed just the opposite; the surprising results suggested women had an increased risk for dementia and mild cognitive impairment. Millions of women stopped taking hormone replacement therapy to protect their bones, improve their mood and ease hot flashes.

The women in the WHIMS study were older, all over age 65. The women in the studies Gleason reviewed were younger when they began taking hormone replacement therapy, usually in their early 50s. And they were healthier, less obese and had fewer heart problems and diabetes.  


The pros and cons of hormone replacement therapy continue to be investigated, and Gleason is planning a follow up study this fall to find out what she calls the final piece of the puzzle: understanding the long-term effects of hormone replacement therapy.

To know more about Alzheimer's and other Neurodegenerative Diseases, Join us at #Alzheimers2018 at Madrid, Spain on December 03-04.

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