Acute Disseminated Encephalomyelitis (ADEM)

Overview

Acute Disseminated Encephalomyelitis (ADEM) is a brief but intense attack of inflammation (swelling) in the brain and spinal cord and occasionally the optic nerves that damages the brain’s myelin (the white coating of nerve fibers). Other terms used to refer to ADEM include post-infectious encephalomyelitis and immune-mediated encephalomyelitis.

ADEM is sometimes difficult to distinguish from multiplesclerosis (MS) because the symptoms common to both "demyelinating" disorders include loss of vision, weakness, numbness and loss of balance. Both ADEM and MS involve immune-mediated responses to myelin in the brain and spinal cord.

What causes ADEM?
The cause of ADEM is not clear but in more than half of the cases, symptoms appear following a viral or bacterial infection, usually a sore throat or cough and very rarely following vaccination. ADEM is thought to be an autoimmune condition where the body’s immune system mistakenly identifies its own healthy cells and tissues as foreign and mounts an attack against them. This attack results in inflammation.  Most cases of ADEM begin about 7 to 14 days after an infection or up to three months following a vaccination. In some cases of ADEM, no preceding event is identified.

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