Gene module is target-rich environment for Alzheimer's pathology, cognitive decline

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A team of NIA-supported researchers, as part of the Accelerating Medicines Partnership for Alzheimer's disease (AMP-AD) Target Discovery and Preclinical Validation consortium has zeroed in on several potential therapeutic targets from a cluster of genes associated with Alzheimer’s disease brain pathology and cognitive decline.
The finding is an important milestone for the AMP-AD program and Alzheimer’s disease research in general, as it demonstrates the power of systems-based modelling approaches to identify causal associations between entire networks of genes and various pathologic and/or clinical traits for Alzheimer’s disease. Known as gene module-trait network (MTN) analysis, this technique gives a more holistic view of molecular targets than traditional single gene associations, focusing on disease-relevant patterns of co-expressed genes that can enable entire gene networks to be therapeutically modulated to more robustly modify the disease process.

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